My research work is in machine learning, data mining, probabilistic modeling and their applications in biomedical informatics.
The main focus of my current research is the development of modern machine learning technologies for analysis of
high dimensional time-series data in electronic health record (EHR) data and their application in
clinical decision support and clinical alerting.
Outlier detection in large clinical databases. Development of
statistical outlier detection methods for identification of unusual outcomes and patient management decisions.
Application to alerting in ICU data streams.
Active learning for intelligent sample collection .
Markov decision processes. Design of
efficient value-function and policy approximation methods for solving
large MDPs. Extensions of MDPs to continuous time, continuous state
and partially observable settings.
Current research funding:
NIH/NIGMS. R01. Detecting deviations in clinical care in ICU data streams (Principal Investigator)
NIH/NLM. R01. Using medical records repositories to improve the alert system design. (Principal Investigator)
NSF. Discovering Complex Anomalous Patterns (co-investigator, PI: Dubrawski, CMU and Cooper, Uiniversity of Pittsburgh)
Machine learning methods for proteomics and genomics. Statistical methods for identification of hidden regulatory pathways
from gene expression data. Algorithms for preprocessing and analysis of high-throughput MS proteomic and genomic data and for biomarker discovery. Methods for protein ID in whole sample proteomics using prior knowledge